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Basic Research Skills Seminar (16 Aug 2017)


Basic Research Skills Seminar

Centre for Genomic Sciences

Classical Genetics –
Segregation and Linkage

Prof Pak Sham

16 August 2017 (Wed) 3:00-4:00pm

Seminar Room 2, G/F
The Hong Kong Jockey Club Building for Interdisciplinary Research
 5 Sassoon Road, Pokfulam, Hong Kong


Classical genetics is based solely on visible results of reproduction (i.e. phenotypes), while the underlying genotypes can only be inferred from observed phenotypes. It dates back to the work of Gregor Mendel, who inferred the existence of discrete units of inheritance (genes) from breeding experiments on the garden pea. Since modern molecular technologies now enable genotypes to be directly and efficiently measured, the relevance of classical genetics to modern research may be questionable. However, an understanding of classical genetics methods and principles is still valuable in many aspects of genetics research. We will describe how classical genetics is helpful in assessing whether a phenotype has a simple genetic (i.e. monogenic) basis, the overall contribution of genetic variation to phenotypic variability of a complex trait in a population, and the overall contribution of genetic variation to phenotypic covariance of two complex traits in a population. We will also describe how the phenomena of linkage and linkage disequilibrium discovered in the era of classical genetics are still useful for mapping the genetic variants that contribute to phenotypic variability in a population.



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