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2014 Research Publications

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  1. Basil, P., Li, Q., Dempster, E. L., Mill, J., Sham, P. C., Wong, C. C., and McAlonan, G. M. (2014) Prenatal maternal immune activation causes epigenetic differences in adolescent mouse brain, Translational psychiatry 4, e434.


  2. Chan, T. K., Hui, E., and Chung, B. (2014) A child born with Edward's syndrome: the legal and moral duty to accede to the request for parentage determination, Journal of medical ethics 40, 383-386.


  3. Cheng, S. T., Chow, P. K., Song, Y. Q., Yu, E. C., and Lam, J. H. (2014) Can leisure activities slow dementia progression in nursing home residents? A cluster-randomized controlled trial, International psychogeriatrics / IPA 26, 637-643.


  4. Cheung, B. M., and Deng, H. B. (2014) Fibroblast growth factor 21: a promising therapeutic target in obesity-related diseases, Expert review of cardiovascular therapy 12, 659-666.


  5. Cheung, C. L., Lam, K., Wong, I., and Cheung, B. (2014) Non-invasive score identifies ultrasonography-diagnosed non-alcoholic fatty liver disease and predicts mortality in the USA, BMC medicine 12, 154.


  6. Cheung, C. L., Sahni, S., Cheung, B. M., Sing, C. W., and Wong, I. C. (2014) Vitamin K intake and mortality in people with chronic kidney disease from NHANES III, Clinical nutrition.


  7. Cheung, C. Y., Hui, E. Y., Cheung, B. M., Woo, Y. C., Xu, A., Fong, C. H., Ong, K. L., Yeung, C. Y., Janus, E. D., Tse, H. F., Sham, P. C., and Lam, K. S. (2014) Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study, European journal of endocrinology / European Federation of Endocrine Societies 171, 107-115.


  8. Cheung, K. M., Lam, C. W., Chan, Y. K., Siu, W. K., and Yong, L. (2014) Atypical focal cortical dysplasia in a patient with Cowden syndrome, Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine 20, 165-167.


  9. Cheung, T. T., and Cheung, B. M. (2014) Managing blood pressure control in Asian patients: safety and efficacy of losartan, Clinical interventions in aging 9, 443-450.


  10. Chong, Y. K., Ma, L. C., Lo, K. L., Lee, C. K., Mak, C. M., Kan, A. N., and Lam, C. W. (2014) Dystroglycanopathy with two novel POMT1 mutations in a Chinese boy with developmental delay and muscular dystrophy, European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 18, 532-535.


  11. Chou, K. L., Cacioppo, J. T., Kumari, M., and Song, Y. Q. (2014) Influence of social environment on loneliness in older adults: Moderation by polymorphism in the CRHR1, The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 22, 510-518.


  12. Chung, B. H., Bradley, T., Grosse-Wortmann, L., Blaser, S., Dirks, P., Hinek, A., and Chitayat, D. (2014) Hand and fibrillin-1 deposition abnormalities in Loeys-Dietz syndrome--expanding the clinical spectrum, American journal of medical genetics. Part A 164A, 461-466.


  13. Chung, B. H., Tao, V. Q., and Tso, W. W. (2014) Copy number variation and autism: new insights and clinical implications, Journal of the Formosan Medical Association = Taiwan yi zhi 113, 400-408.


  14. Falchi, M., El-Sayed Moustafa, J. S., Takousis, P., Pesce, F., Bonnefond, A., Andersson-Assarsson, J. C., Sudmant, P. H., Dorajoo, R., Al-Shafai, M. N., Bottolo, L., Ozdemir, E., So, H. C., Davies, R. W., Patrice, A., Dent, R., Mangino, M., Hysi, P. G., Dechaume, A., Huyvaert, M., Skinner, J., Pigeyre, M., Caiazzo, R., Raverdy, V., Vaillant, E., Field, S., Balkau, B., Marre, M., Visvikis-Siest, S., Weill, J., Poulain-Godefroy, O., Jacobson, P., Sjostrom, L., Hammond, C. J., Deloukas, P., Sham, P. C., McPherson, R., Lee, J., Tai, E. S., Sladek, R., Carlsson, L. M., Walley, A., Eichler, E. E., Pattou, F., Spector, T. D., and Froguel, P. (2014) Low copy number of the salivary amylase gene predisposes to obesity, Nature genetics 46, 492-497.


  15. Gui, H., Bao, J. Y., Tang, C. S., So, M. T., Ngo, D. N., Tran, A. Q., Bui, D. H., Pham, D. H., Nguyen, T. L., Tong, A., Lok, S., Sham, P. C., Tam, P. K., Cherny, S. S., and Garcia-Barcelo, M. M. (2014) Targeted next-generation sequencing on hirschsprung disease: a pilot study exploits DNA pooling, Annals of human genetics 78, 381-387.


  16. Gui, H., Jiang, C. Q., Cherny, S. S., Sham, P. C., Xu, L., Liu, B., Jin, Y. L., Zhu, T., Zhang, W. S., Thomas, G. N., Cheng, K. K., and Lam, T. H. (2014) Influence of Alzheimer's disease genes on cognitive decline: the Guangzhou Biobank Cohort Study, Neurobiology of aging 35, 2422 e2423-2428.


  17. Ho, A. C., Fung, C. W., Siu, T. S., Ma, O. C., Lam, C. W., Tam, S., and Wong, V. C. (2014) Lathosterolosis: a disorder of cholesterol biosynthesis resembling smith-lemli-opitz syndrome, JIMD reports 12, 129-134.


  18. Hui, C. L., Chang, W. C., Chan, S. K., Lee, E. H., Tam, W. W., Lai, D. C., Wong, G. H., Tang, J. Y., Li, F. W., Leung, K. F., McGhee, S. M., Sham, P. C., and Chen, E. Y. (2014) Early intervention and evaluation for adult-onset psychosis: the JCEP study rationale and design, Early intervention in psychiatry 8, 261-268.


  19. Hui, E., Xu, A., Chow, W. S., Lee, P. C., Fong, C. H., Cheung, S. C., Tse, H. F., Chau, M. T., Cheung, B. M., and Lam, K. S. (2014) Hypoadiponectinemia As An Independent Predictor for the Progression of Carotid Atherosclerosis: A 5-Year Prospective Study, Metabolic syndrome and related disorders.


  20. Kam, M. K., Cheung, M. C., Zhu, J. J., Cheng, W. W., Sat, E. W., Tam, P. K., and Lui, V. C. (2014) Perturbation of Hoxb5 signaling in vagal and trunk neural crest cells causes apoptosis and neurocristopathies in mice, Cell death and differentiation 21, 278-289.


  21. Kam, M. K., Cheung, M., Zhu, J. J., Cheng, W. W., Sat, E. W., Tam, P. K., and Lui, V. C. (2014) Homeobox b5 (Hoxb5) regulates the expression of Forkhead box D3 gene (Foxd3) in neural crest, The international journal of biochemistry & cell biology 55C, 144-152.


  22. Kan, A. S., Lau, E. T., Tang, W. F., Chan, S. S., Ding, S. C., Chan, K. Y., Lee, C. P., Hui, P. W., Chung, B. H., Leung, K. Y., Ma, T., Leung, W. C., and Tang, M. H. (2014) Whole-genome array CGH evaluation for replacing prenatal karyotyping in Hong Kong, PloS one 9, e87988.


  23. Ko, J. M., Zhang, P., Law, S., Fan, Y., Song, Y. Q., Zhao, X. K., Wong, E. H., Tang, S., Song, X., Lung, M. L., and Wang, L. D. (2014) Identity-by-descent approaches identify regions of importance for genetic susceptibility to hereditary esophageal squamous cell carcinoma, Oncology reports 32, 860-870.


  24. Kwan, J. S., Hsu, Y. H., Cheung, C. L., Dupuis, J., Saint-Pierre, A., Eriksson, J., Handelman, S. K., Aragaki, A., Karasik, D., Pramstaller, P. P., Kooperberg, C., Lacroix, A. Z., Larson, M. G., Lau, K. S., Lorentzon, M., Pichler, I., Sham, P. C., Taliun, D., Vandenput, L., Kiel, D. P., Hicks, A. A., Jackson, R. D., Ohlsson, C., Benjamin, E. J., and Kung, A. W. (2014) Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels, Human molecular genetics.


  25. Kwok, H., Wu, C. W., Palser, A. L., Kellam, P., Sham, P. C., Kwong, D. L., and Chiang, A. K. (2014) Genomic diversity of epstein-barr virus genomes isolated from primary nasopharyngeal carcinoma biopsy samples, Journal of virology 88, 10662-10672.


  26. Lam, C. W. (2014) PrimeIndel: four-prime-number genetic code for indel decryption and sequence read alignment, Clinica chimica acta; international journal of clinical chemistry 436, 1-4.


  27. Lam, C. W., and Law, C. Y. (2014) Pleural effusion lipoproteins measured by NMR spectroscopy for diagnosis of exudative pleural effusions: a novel tool for pore-size estimation, Journal of proteome research 13, 4104-4112.


  28. Lam, C. W., and Law, C. Y. (2014) Untargeted mass spectrometry-based metabolomic profiling of pleural effusions: Fatty acids as novel cancer biomarkers for malignant pleural effusions, Journal of proteome research 13, 4040-4046.


  29. Lam, C. W., Law, C. Y., Sze, K. H., and To, K. K. (2014) Quantitative metabolomics of urine for rapid etiological diagnosis of urinary tract infection: Evaluation of a microbial-mammalian co-metabolite as a diagnostic biomarker, Clinica chimica acta; international journal of clinical chemistry 438C, 24-28.


  30. Lam, C. W., Law, C. Y., To, K. K., Cheung, S. K., Lee, K. C., Sze, K. H., Leung, K. F., and Yuen, K. Y. (2014) NMR-based metabolomic urinalysis: a rapid screening test for urinary tract infection, Clinica chimica acta; international journal of clinical chemistry 436, 217-223.


  31. Lam, L. C., Chan, W. C., Wong, C. S., Chen, E. Y., Ng, R. M., Lee, E. H., Chang, W. C., Hung, S. F., Cheung, E. F., Sham, P. C., Chiu, H. F., Lam, M., Chiang, T. P., van Os, J., Lau, J. T., Lewis, G., Bebbington, P., and Hong Kong Mental Morbidity Survey, T. (2014) The Hong Kong mental morbidity survey: background and study design, East Asian archives of psychiatry : official journal of the Hong Kong College of Psychiatrists = Dong Ya jing shen ke xue zhi : Xianggang jing shen ke yi xue yuan qi kan 24, 30-36.


  32. Lau, S. T., Hansford, L. M., Chan, W. K., Chan, G. C., Wan, T. S., Wong, K. K., Kaplan, D. R., Tam, P. K., and Ngan, E. S. (2014) Prokineticin signaling is required for the maintenance of a de novo population of c-KIT cells to sustain neuroblastoma progression, Oncogene 0.


  33. Law, C. Y., Lam, C. W., Ching, C. K., Yau, K. C., Ho, T. W., Lai, C. K., and Mak, C. M. (2014) NMR-based urinalysis for beta-ketothiolase deficiency, Clinica chimica acta; international journal of clinical chemistry 438C, 222-225.


  34. Lee, H. H., Mak, C. M., Poon, G. W., Wong, K. Y., and Lam, C. W. (2014) Cost-benefit analysis of Hyperphenylalaninemia Due to 6-Pyruvoyl-Tetrahydropterin Synthase (PTPS) Deficiency: For Consideration of Expanded Newborn Screening in Hong Kong, Journal of medical screening 21, 61-70.


  35. Lee, P. P., Mao, H., Yang, W., Chan, K. W., Ho, M. H., Lee, T. L., Chan, J. F., Woo, P. C., Tu, W., and Lau, Y. L. (2014) Penicillium marneffei infection and impaired IFN-gamma immunity in humans with autosomal-dominant gain-of-phosphorylation STAT1 mutations, The Journal of allergy and clinical immunology 133, 894-896 e895.


  36. Li, C., Cheung, C. L., Cheung, T. T., Samaranayake, N. R., and Cheung, B. M. (2014) Hay fever and hypertension in the US adult population, Clinical and experimental hypertension 36, 206-210.


  37. Li, M. J., Wang, L. Y., Xia, Z., Wong, M. P., Sham, P. C., and Wang, J. (2014) dbPSHP: a database of recent positive selection across human populations, Nucleic acids research 42, D910-916.


  38. Li, M., Ho, P. W., Pang, S. Y., Tse, Z. H., Kung, M. H., Sham, P. C., and Ho, S. L. (2014) PMCA4 (ATP2B4) Mutation in Familial Spastic Paraplegia, PloS one 9, e104790.


  39. Liu, A. P., Chow, P. C., Lee, P. P., Mok, G. T., Tang, W. F., Lau, E. T., Lam, S. T., Chan, K. Y., Kan, A. S., Chau, A. K., Cheung, Y. F., Lau, Y. L., and Chung, B. H. (2014) Under-recognition of 22q11.2 deletion in adult Chinese patients with conotruncal anomalies: implications in transitional care, European journal of medical genetics 57, 306-311.


  40. Londono, D., Kou, I., Johnson, T. A., Sharma, S., Ogura, Y., Tsunoda, T., Takahashi, A., Matsumoto, M., Herring, J. A., Lam, T. P., Wang, X., Tam, E. M., Song, Y. Q., Fan, Y. H., Chan, D., Cheah, K. S., Qiu, X., Jiang, H., Huang, D., Japanese Scoliosis Clinical Research, G., Group, T. I. C., International Consortium for Scoliosis, G., Su, P., Sham, P., Cheung, K. M., Luk, K. D., Gordon, D., Qiu, Y., Cheng, J., Tang, N., Ikegawa, S., and Wise, C. A. (2014) A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups, Journal of medical genetics 51, 401-406.


  41. Luk, H. M., Wong, V. C., Lo, I. F., Chan, K. Y., Lau, E. T., Kan, A. S., Tang, M. H., Tang, W. F., She, W. M., Chu, Y. W., Sin, W. K., and Chung, B. H. (2014) A prenatal case of split-hand malformation associated with 17p13.3 triplication - a dilemma in genetic counseling, European journal of medical genetics 57, 81-84.


  42. Mak, H. K., Qian, W., Ng, K. S., Chan, Q., Song, Y. Q., Chu, L. W., and Yau, K. K. (2014) Combination of MRI hippocampal volumetry and arterial spin labeling MR perfusion at 3-Tesla improves the efficacy in discriminating Alzheimer's disease from cognitively normal elderly adults, Journal of Alzheimer's disease : JAD 41, 749-758.


  43. Ng, R. C., Matsumaru, D., Ho, A. S., Garcia-Barcelo, M. M., Yuan, Z. W., Smith, D., Kodjabachian, L., Tam, P. K., Yamada, G., and Lui, V. C. (2014) Dysregulation of Wnt inhibitory factor 1 (Wif1) expression resulted in aberrant Wnt-beta-catenin signaling and cell death of the cloaca endoderm, and anorectal malformations, Cell death and differentiation 21, 978-989.


  44. Ong, K. L., Allison, M. A., Cheung, B. M., Wu, B. J., Barter, P. J., and Rye, K. A. (2014) The relationship between total bilirubin levels and total mortality in older adults: the United States National Health and Nutrition Examination Survey (NHANES) 1999-2004, PloS one 9, e94479.


  45. Ong, K. L., McClelland, R. L., Rye, K. A., Cheung, B. M., Post, W. S., Vaidya, D., Criqui, M. H., Cushman, M., Barter, P. J., and Allison, M. A. (2014) The relationship between insulin resistance and vascular calcification in coronary arteries, and the thoracic and abdominal aorta: The Multi-Ethnic Study of Atherosclerosis, Atherosclerosis 236, 257-262.


  46. Samaranayake, N. R., Cheung, S. T., Cheng, K., Lai, K., Chui, W. C., and Cheung, B. M. (2014) Implementing a bar-code assisted medication administration system: effects on the dispensing process and user perceptions, International journal of medical informatics 83, 450-458.


  47. Schizophrenia Working Group of the Psychiatric Genomics, C. (Sham, P. C., Li, M. X.) (2014) Biological insights from 108 schizophrenia-associated genetic loci, Nature 511, 421-427.


  48. Sham, P. C., and Purcell, S. M. (2014) Statistical power and significance testing in large-scale genetic studies, Nature reviews. Genetics 15, 335-346.


  49. Song, E., Fan, P., Huang, B., Deng, H. B., Cheung, B. M., Feletou, M., Vilaine, J. P., Villeneuve, N., Xu, A., Vanhoutte, P. M., and Wang, Y. (2014) Deamidated lipocalin-2 induces endothelial dysfunction and hypertension in dietary obese mice, Journal of the American Heart Association 3, e000837.


  50. Tam, E. W., Chen, J. H., Lau, E. C., Ngan, A. H., Fung, K. S., Lee, K. C., Lam, C. W., Yuen, K. Y., Lau, S. K., and Woo, P. C. (2014) Misidentification of Aspergillus nomius and Aspergillus tamarii as Aspergillus flavus: characterization by internal transcribed spacer, beta-Tubulin, and calmodulin gene sequencing, metabolic fingerprinting, and matrix-assisted laser desorption ionization-time of flight mass spectrometry, Journal of clinical microbiology 52, 1153-1160.


  51. Tang, J. Y., Chang, W. C., Hui, C. L., Wong, G. H., Chan, S. K., Lee, E. H., Yeung, W. S., Wong, C. K., Tang, W. N., Chan, W. F., Pang, E. P., Tso, S., Ng, R. M., Hung, S. F., Dunn, E. L., Sham, P. C., and Chen, E. Y. (2014) Prospective relationship between duration of untreated psychosis and 13-year clinical outcome: a first-episode psychosis study, Schizophrenia research 153, 1-8.


  52. Thomas, G. N., Macfarlane, D. J., Guo, B., Cheung, B. M., McGhee, S. M., Chou, K. L., Deeks, J. J., Lam, T. H., and Tomlinson, B. (2014) Pedometry and 'peer support' in older Chinese adults: a 12-month cluster randomised controlled trial, Hong Kong medical journal = Xianggang yi xue za zhi / Hong Kong Academy of Medicine 20, 11-14.


  53. Wong, E. H., So, H. C., Li, M., Wang, Q., Butler, A. W., Paul, B., Wu, H. M., Hui, T. C., Choi, S. C., So, M. T., Garcia-Barcelo, M. M., McAlonan, G. M., Chen, E. Y., Cheung, E. F., Chan, R. C., Purcell, S. M., Cherny, S. S., Chen, R. R., Li, T., and Sham, P. C. (2014) Common variants on Xq28 conferring risk of schizophrenia in Han Chinese, Schizophrenia bulletin 40, 777-786.


  54. Wong, H. K., Ong, K. L., Cheung, C. L., and Cheung, B. M. (2014) Utilization of glucose, blood pressure, and lipid lowering medications among people with type II diabetes in the United States, 1999-2010, Annals of epidemiology 24, 516-521 e511.


  55. Wong, H. K., Tang, F., Cheung, T. T., and Cheung, B. M. (2014) Adrenomedullin and diabetes, World journal of diabetes 5, 364-371.


  56. Yalamanchili, H. K., Yan, B., Li, M. J., Qin, J., Zhao, Z., Chin, F. Y., and Wang, J. (2014) DDGni: dynamic delay gene-network inference from high-temporal data using gapped local alignment, Bioinformatics 30, 377-383.


  57. Yang, W., and Lau, Y. L. (2014) Solving the genetic puzzle of systemic lupus erythematosus, Pediatric nephrology.


  58. Yeung, K., Chee, Y., Luk, H., Kan, A. S., Tang, M. H., Lau, E. T., Shuen, A. Y., Lo, I. F., Chan, K. Y., and Chung, B. H. (2014) Spread of X inactivation on chromosome 15 is associated with a more severe phenotype in a girl with an unbalanced t(X; 15) translocation, American journal of medical genetics. Part A 164, 2521-2528.


  59. Zeng, S., Yang, J., Chung, B. H., Lau, Y. L., and Yang, W. (2014) EFIN: predicting the functional impact of nonsynonymous single nucleotide polymorphisms in human genome, BMC genomics 15, 455.


  60. Zhang, Y., Zhang, J., Yang, J., Wang, Y., Zhang, L., Zuo, X., Sun, L., Pan, H. F., Hirankarn, N., Wang, T., Chen, R., Ying, D., Zeng, S., Shen, J. J., Lee, T. L., Lau, C. S., Chan, T. M., Leung, A. M., Mok, C. C., Wong, S. N., Lee, K. W., Ho, M. H., Lee, P. P., Chung, B. H., Chong, C. Y., Wong, R. W., Mok, M. Y., Wong, W. H., Tong, K. L., Tse, N. K., Li, X. P., Avihingsanon, Y., Rianthavorn, P., Deekajorndej, T., Suphapeetiporn, K., Shotelersuk, V., Ying, S. K., Fung, S. K., Lai, W. M., Wong, C. M., Ng, I. O., Garcia-Barcelo, M. M., Cherny, S. S., Tam, P. K., Sham, P. C., Yang, S., Ye, D. Q., Cui, Y., Zhang, X. J., Lau, Y. L., and Yang, W. (2014) Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus, Human molecular genetics.


  61. Zhou, K., Donnelly, L., Yang, J., Li, M., Deshmukh, H., Van Zuydam, N., Ahlqvist, E., Wellcome Trust Case Control, C., Spencer, C. C., Groop, L., Morris, A. D., Colhoun, H. M., Sham, P. C., McCarthy, M. I., Palmer, C. N., and Pearson, E. R. (2014) Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis, The lancet. Diabetes & endocrinology 2, 481-487.


  62. Zhu, J. J., Kam, M. K., Garcia-Barcelo, M. M., Tam, P. K., and Lui, V. C. (2014) HOXB5 binds to multi-species conserved sequence (MCS+9.7) of RET gene and regulates RET expression, The international journal of biochemistry & cell biology 51, 142-149.