Home Research Publications

2005 - 2010 Research Publications



  1. Lok S.  Methods for nucleic acid mapping and identification of structural-variations in nucleic acids and utilities.  European Patent 1,969,146 (Issued 6-Oct-2010).

  2. Campbell DD, Sham PC, Knight J, Wickham H, Landau S (2010).  Software for generating liability distributions for pedigrees conditional on their observed disease states and covariates.  Genet Epidemiol 34(2): 159-70.

  3. Cheung CYY, Tso AWK, Cheung BMY, Xu AM, Ong KL, Fong CHY, Wat NMS, Janus ED, Sham PC, Lam KSL (2010).  Obesity susceptibility genetic variants identified from recent genome-wide association studies: implications in a chinese population.  J Clin Endocrinol Metab 95:1395-403.

  4. Ching JCY, Chan KYK, Lee EHL, Xu MS, Ting CKP, So TMK, Sham PC, Leung GM, Peiris JSM, Khoo US (2010).  Significance of the myxovirus resistance a (MXA) gene-123c > a single-nucleotide polymorphism in suppressed interferon beta induction of severe acute respiratory syndrome coronavirus infection.  J Infect Dis 201:1899-908.

  5. Cornes BK, Tang CS, Leon TYY, Hui K, So MT, Miao XP, Cherny SS, Sham PC, Tam PKH, Garcia-Barcelo MM (2010).  Haplotype analysis reveals a possible founder effect of RET mutation R114H for Hirschsprung's disease in the chinese population.  PLoS One 5(6): e10918.

  6. Kung AWC, Xiao SM, Cherny S, Li GHY, Gao Y, Tso G, Lau KS, Luk KDK, Liu JM, Cui B, Zhang MJ, Zhang ZL, He JW, Yue H, Xia WB, Luo LM, He SL, Kiel DP, Karasik D, Hsu YH, Cupples LA, Demissie S, Styrkarsdottir U, Halldorsson BV, Sigurdsson G, Thorsteinsdottir U, Stefansson K, Richards JB, Zhai GJ, Soranzo N, Valdes A, Spector TD, Sham PC (2010).  Association of JAG1 with bone mineral density and osteoporotic fractures: A genome-wide association study and follow-up replication studies.  Am J Hum Genet 86(2): 229-39.

  7. Liu Y, Li M, Cheung YM, Sham PC, Ng MK (2010).  SKM-SNP: SNP markers detection method.  J Biomed Inform 43(2): 233-39.

  8. Ong KL, Tso AWK, Cherny SS, Sham PC, Lam KSL, Jiang CQ, Thomas GN, Lams TH, Cheung BMY (2010).  A genetic variant in the gene encoding fibrinogen beta chain predicted development of hypertension in Chinese men.  Thromb Haemost 103(4): 728-35.

  9. Rahman ML, Bunce C, Healey PR, Mitchell P, Sham PC, McGuffin P, Viswanathan AC (2010).  Commingling analyses of central corneal thickness and adjusted intraocular pressure in an older australian population.  Invest Ophthalmol Vis Sci 51(5): 2512-18.

  10. So HC, Fong PY, Chen RYL, Hui TCK, Ng MYM, Cherny SS, Mak WWM, Cheung EFC, Chan RCK, Chen EYH, Li T, Sham PC (2010).  Identification of Neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.  Am J Med Genet B 153B(1): 103-13.

  11. Tang CS, Sribudiani Y, Miao XP, de Vries AR, Burzynski G, So MT, Leon YY, Yip BH, Osinga J, Hui K, Verheij J, Cherny SS, Tam PKH, Sham PC, Hofstra RMW, Garcia-Barcelo MM (2010).  Fine mapping of the 9q31 Hirschsprung's disease locus.  Hum Genet 127(6): 675-83.

  12. Tomlinson IPM, Dunlop M, Campbell H, Zanke B, Gallinger S, Hudson T, Koessler T, Pharoah PD, Niittymaki I, Tuupanen S, Aaltonen LA, Hemminki K, Lindblom A, Forsti A, Sieber O, Lipton L, van Wezel T, Morreau H, Wijnen JT, Devilee P, Matsuda K, Nakamura Y, Castellvi-Bel S, Ruiz-Ponte C, Castells A, Carracedo A, Ho JWC, Sham PC, Hofstra RMW, Vodicka P, Brenner H, Hampe J, Schafmayer C, Tepel J, Schreiber S, Volzke H, Lerch MM, Schmidt CA, Buch S, Moreno V, Villanueva CM, Peterlongo P, Radice P, Echeverry MM, Velez A, Carvajal-Carmona L, Scott R, Penegar S, Broderick P, Tenesa A, Houlston RS (2010).  COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer.  Br J Cancer 102(2): 447-454.

  13. Yang WL, Shen N, Ye DQ, Liu QJ, Zhang Y, Qian XX, Hirankarn N, Ying DG, Pan HF, Mok CC, Chan TM, Wong RWS, Lee KW, Mok MY, Wong SN, Leung AMH, Li XP, Avihingsanon Y, Wong CM, Lee TL, Ho MHK, Lee PPW, Chang YK, Li PH, Li RJ, Zhang L, Wong WHS, Ng IOL, Lau CS, Sham PC, Lau YL, Asian Lupus Genbetics Consortium (ALGC) (2010).  Genome-wide association study in asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.  PLoS Genet. 6(2): e1000841.


  1. Cherny SS (2009).  QTL methodology in behavior genetics. In Kim (ed), Handbook of behavior genetics, (pp 35-45) Springer, NY.

  2. Yeung DCY, Xu AM, Tso AWK, Chow WS, Wat NMS, Fong CHY, Tam S, Sham PC, Lam KSL (2009).  Circulating levels of adipocyte and epidermal fatty acid-binding proteins in relation to nephropathy staging and macrovascular complications in type 2 diabetic patients.  Diabetes Care 32: 132-134.  (Jan 2009)

  3. Zhong SF, Chew SH, Set E, Zhang JS, Xue H, Sham PC, Ebstein RP, Israel S (2009).  The heritability of attitude toward economic risk.  Twin Res Hum Genet 12: 103-107.  (Jan 2009)

  4. Jawaid A, Sham PC (2009).  Impact and quantification of the sources of error in DNA pooling designs.  Ann Hum Genet 73: 118-124.  (Jan 2009)

  5. Wang Y, Leung FCC (2009).  In silico prediction of honeybee (Apis mellifera) genes under regulation of DNA methylation and sorting according to Gene Ontology terms.  J Mol Evol 68: 700-705.  (Jan 2009)

  6. Cheung C., Chan BYY, Chan V, Ikegawa S, Kou I, Ngai H, Smith D, Luk KDK, Huang QY, Mori S, Sham PC, et al (2009).  Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.  Hum Mol Genet 18: 679-687.  (Feb 2009)

  7. Simpson CL, Lemmens R, Miskiewicz K, Broom WJ, Hansen VK, van Vught PWJ, Landers JE, Sapp P, Van Den Bosch L, Knight J, Sham PC, et al (2009).  Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration.  Hum Mol Genet 18: 472-481.  (Feb 2009)

  8. Garcia-Barcelo MM, Tang CSM, Ngan ESW, Lui VCH, Chen Y, So MT, Leon TYY, Miao XP, Shum CKY, Liu FQ, Yeung MY, Yuan ZW, Guo WH, Liu L, Sun XB, Huang LM, Tou JF, Song YQ, Chan D, Cheung KMC, Wong KKY, Cherny SS, Sham PC, Tam PKH (2009).  Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung’s disease.  Proc Natl Acad Sci (USA) 196: 2694-2699.  (Feb 2009)

  9. Ngan ESW, Lang BHH, Liu T, Shum CKY, So M-T, Lau DKC, Leon TYY, Cherny SS, Tsai SY, Lo C-Y, Khoo U-S, Tam PKH, Garcia-Barcelo MM (2009).  A germline mutation (A339V) in Thyroid Transcription Factor-1 (TITF-1/ NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma.  J Natl Cancer Inst 101: 162-175.  (Feb 2009)

  10. Woo* PCY, Lau* SKP, Tse* H, Teng* JLL, Curreem SOT, Tsang AKL, Fan RYY, Wong GKM, Huang Y, Loman NJ, Synder LAS, Cai JJ, Huang J-D, Mak W, Pallen MJ, Lok S, Yuen K-Y (2009).  The complete genome and proteome of Laribacter kongkongensis reveal potential mechanisms for adaptations to different temperature and habitats.  PLoS Genetics 5: e1000416.  (Mar 2009)

  11. Li M, Cheng TS, Ho PWL, Chan KH, Mak W, Cheung RTF, Ramsden DB, Sham PC, Song YQ, Ho SL (2009).  -459C > T point mutation in 5' non-coding region of human GJB1 gene is linked to X-linked Charcot-Marie-Tooth neuropathy.  Journal of the Peripheral Nervous System 14: 14-21.  (Mar 2009)

  12. Liang LM, Chen WM, Sham PC, Abecasis GR (2009).  Variance components linkage analysis with repeated measurements.  Hum Heredity 67: 237-247.  (Mar 2009)

  13. Wang Y, Leung FCC (2009).  A study on genomic distribution and sequence features of human long inverted repeats reveals species-specific intronic stem-loops.  FEBS J 276: 1986-1998.  (April 2009)

  14. Brocklebank D, Gayan J, Andresen JM, Roberts SA, The US-Venezula collaborative research group, Young AB, Snodgrass SR, Penney JB, Ramos MA, Cherny SS, Wexler NS, Housman DE, Cardon LR (2008).  Repeat instability in the 27-39 CAG range of the HD gene in the Venezuelan kindreds: Counseling implications.  Am J Med Genet B Neuropsychiatr Genet 150B: 425-429.  (April 2009)

  15. Wang Y, Leung FCC (2009).  Acquisition of inverted GSTM exons by an intron of primate GSTM5 gene.  J Hum Genet 54: 271-276.  (May 2009)

  16. Cheung BMY, Ong KL, Cherny SS, Sham PC, Tso AWK, Lam KSL (2009).  Diabetes prevalence and therapeutic target achievement in the United States, 1999 to 2006.  Am J Med 122: 443-453.  (May 2009)

  17. Wang Y, Leung FCC (2009).  Comparative genomic study on context-dependence of CpG mutations: Acceleration effect of 5’ T nucleotides and new evidence of strand asymmetry in genes.  Online Journal of Bioinformatics 10: 165-179.

  18. Ong KL, Leung RYH, Babinska A, Salifu MO, Whrlich YH, Kornecki E, Wong LYF, Tso AWK, Cherny SS, Sham PC, Lam TH, Lam KSL, Cheung BMY (2009).  Elevated plasma level of soluble F11 receptor/junctional adhesion molecule-A (F11R/JAM-A) in hypertension.  Am J Hypertens 22: 500-505.  (May 2009)

  19. Sham PC, Cherny SS, Purcell S (2009).  Application of genome-wide SNP data for uncovering pair-wise relationship and quantitative trait loci.  Genetica 136: 237-243.  (June 2009)

  20. Li MX, Jiang L, Kao PYP, Sham PC, Song YQ (2009).  IGG3: a tool to rapidly integrate large genotype datasets for whole-genome imputation and individual-level meta-analysis.  Bioinformatics 25: 1449-1450.  (June 2009)

  21. Yang WL, Zhao MH, Hirankarn N, Lau C., Mok CC, Chan TM, Wong RWS, Lee KW, Mok MY, Wong SN, Sham PC, et al (2009).  ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai.  Hum Mol Genet 18: 2063-2070.  (June 2009)

  22. Wang Y, Leung FCC (2009).  Discovery of a long inverted repeat in human POTE genes.  Genomics 94(4): 278-283.  (Oct 2009)

  23. Kwan JSH, Cherny SS, Kung, AWC, Sham PC (2009).  Novel sib-pair selection strategy increases power in quantitative association analysis.  Behavior Genetics 39(5): 571-579.

  24. * Co-first author
    ** Print date is denoted in brackets


  1. Cherny SS (2008). Chapter 9: Regression methods for linkage analysis.  In Neale BM, Ferreira MAR, Medland SE, Posthuma D (eds.), Statistical genetics: Gene Mapping through Linkage and Association (pp. 153).  Taylor and Francis, UK; http://genemapping.org.

  2. So HC, Chen RYL, Chen EYH, Cheung EFC, Li T, Sham PC (2008).  An association study of RGS4 polymorphisms with clinical phenotypes of Schizophrenia in a Chinese Population.  Am J Med Genet Part B Neuropsychiatr Genet 147B: 77-85.  (Jan 2008)

  3. Wang Yu, Lam KS, Yau MH, Xu A (2008).  Post-translational modifications of adiponectin: Mechanisms and functional implications.  Biochem J 409: 623-633.  (Feb 2008)

  4. Ong KL, Leung RYH, Wong LYF, Cherny SS, Sham PC, Lam TH, Lam KSL, Cheung BYM (2008).  Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men.  Am J Hypertens 21: 539-545.  (Mar 2008)

  5. Ong KL, Leung RYH, Wong LYF, Cherny SS, Sham PC, Lam TH, Lam KSL, Cheung BYM (2008).  Association of F11 receptor gene polymorphisms with central obesity and blood pressure.  J Intern Med 253: 322-332.  (Mar 2008)

  6. Wang Y, Zeng F, Hon CC, Zhang Y, Leung FCC (2008).  The mitochondrial genome of the Basidiomycete fungus Pleurotus ostreatus (oyster mushroom).  FEMS Microbiol Lett 280: 34-41.  (Mar 2008)

  7. Wang* Yu, Yang* YH, Lam KS, Yau MH, Cheng KK, Zhang J, Zhu W, Wu D, Xu A (2008).  Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by carboxyl terminus of angiopoietin-like protein 4.  Arterioscler Thromb Vas Biol 28: 835-840.  (May 2008)

  8. Tomlinson IPM, Webb E, Carvajal-Carmona L, Broderick P, Howarth K, Pittman AM, Spain S, Lubbe S, Walther A, Sullivan K, … Sham PC, et al (2008).  A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.  Nature Genetics 40: 623-630.  (May 2008)

  9. Lee NPY, Leung KW, Cheung N, Lam BY, Xu MZ, Sham PC, Lau GK, Poon RTP, Fan ST, Luk JM (2008). Comparative proteomic analysis of mouse livers from embryo to adult reveals an association with progression of hepatocellular carcinoma. Proteomics 8: 2136-2149. (May 2008)

  10. Dyment DA, Cader MZ, Datta A, Broxholme SJ, Cherny SS, Willer CJ, Ramagopalan S, Herrera BM, Orton SM, Chao M, Sadovnick AD, Hader M, Hader W, Ebers GC (2008).  A first stage genome-wide screen for regions shared identical-by-decent in Hutterite families with multiple sclerosis.  Am J Med Genet Part B Neuropsychiatr Genet 147B: 467-472.  (June 2008)

  11. Garcia-Barcelo MM, Fong PY, Tang CS, Miao XO, So MT, Yuan ZW, Li L, Guo WH, Liu L, Wang B, Sun XB, Huang LM, Tou JF, Wong KKY, Ngan ESW, Lui VCH, Cherny SS, Sham PC, Tam PKH (2008).  Mapping of a Hirschsprung’s disease locus in 3p21.  Eur J Hum Genet 16: 833-840.  (July 2008)

  12. Gayan J, Brocklebank D, Andresen JM, Alkorata-Aranburu G, The US-Venezula collaborative research group, Cader MZ, Roberts SA, Cherny SS, Wexler NS, Cardon LR, Housman DE (2008).  Genome-wide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds.  Genet Epidemiol 32: 445-453.  (July 2008)

  13. Wang Yu, Seneviratne J (2008).  Biomarker discovery in clinical proteomics: Strategies for exposing low abundant proteins.  Curr Proteomics 5: 104-114.  (July 2008)

  14. Seneviratne CJ, Wang Yu, Jin L, Abiko Y, Samaranayake LP (2008).  Canadida albicans biofilm formation is associated with increased anti-oxidative capacities.  Proteomics 8: 2936-2947.  (July 2008)

  15. Li MX, Jiang L, Song YQ, Sham PC (2008).  Power of transmission/disequilibrium tests in admixed populations.  Genet Epidemiol 32: 434-444.  (July 2008)

  16. Hall MH, Schulze K, Sham PC, Kalidindi S, McDonald C, Bramon E, Levy DL, Murray RM, Rijsdijk F (2008).  Further evidence for shared genetic effects between psychotic bipolar disorder and p50 suppression: A combined twin and family study.  Am J Med Genet Part B Neuropsychiatr Genet 147B: 619-627.  (July 2008)

  17. Pittman AM, Webb E, Carvajal-Carmona L, Howarth K, Di Bernardo MC, Broderick P, Spain S, Walther A, Price A, Sullivan K, … Sham PC et al (2008).  Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer.  Hum Mol Genet 17: 3720-3727.  (July 2008)

  18. Bramon E, Dempster E, Frangou S, Shaikh M, Walshe M, Filbey FM, McDonald C, Sham PC, Collier DA, Murray R (2008).  Neuregulin-1 and the P300 waveform - A preliminary association study using a psychosis endophenotype.  Schizophrenia Research 103: 178-185.  (Aug 2008)

  19. Qin YR, Fu L, Sham PC, Kwong DLW, Zhu CL, Chu KKW, Li Y, Guan XY (2008).  Single-nucleotide polymorphism-mass array reveals commonly deleted regions at 3p22 and 3p14.2 associate with poor clinical outcome in esophageal squamous cell carcinoma.  Intl J Cancer 123: 826-830.  (Aug 2008)

  20. Song YQ, Sham PC, Cheung KMC, Chan D (2008).  Genetics of disc degeneration.  Curr Orthopaedics 22: 259-266.  (Aug 2008)

  21. Ho DWH, Chan D, Cheung KMC, Sham PC, Song YQ (2008).  Family-based linkage and case control association studies.  Curr Orthopaedics 22: 245-250.  (Aug 2008)

  22. Sham PC, Cherny SS, Kao PYP, Song YQ, Chan D, Cheung KMC (2008).  Whole-genome association studies of complex diseases.  Curr Orthopaedics 22: 251-258.  (Aug 2008)

  23. Zhang FZ, Sham PC, Fan H, Xu Y, Huang XZ, So HC, Song YQ, Liu PZ (2008).  An association study of ADSS gene polymorphisms with schizophrenia.  Behavioral and Brain Functions 4: 39-44.  (Aug 2008)

  24. Garcia-Barcelo MM, Lui VCH, Miao XP, So MT, Leon TYY, Yuan ZW, Li L, Liu L, Wang B, Sun XB, Huang LM, Tou JF, Ngan ESW, Cherny SS, Wang W, Wong KKY, Tam PKH (2008).  Mutational analysis of SHH and GLI3 in anorectal malformations.  Birth Defect Research A: Clinical and Molecular Teratology 82: 644-648.  (Sept 2008)

  25. Knight J, Curtis D, Sham PC (2008).  CLUMPHAP: A simple tool for performing haplotype-based association analysis.  Genet Epidemiol 32: 539-545.  (Sept 2008)

  26. Yeung DCY, Wang Y, Xu A, Cheung SCW, Wat NMS, Fong DYT, Fong CHY, Chau MT, Sham PC, Lam KSL (2008).  Epidermal fatty-acid-binding protein: a new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis.  Eur Heart J 29: 2156-2163.  (Sept 2008)

  27. Vassos E, Ma XH, Fiotti N, Wang D, Sham PC, Liu XH, Wang YC, Yan CY, Meng HQ, Deng W, Collier DA, Li T (2008).  The functional MMP-9 microsatellite marker is not associated with episodic memory in humans.  Psychiatric Genetics 18: 252-252.  (Oct 2008)

  28. Vassos E, Sham PC, Cai GQ, Deng H, Liu XH, Sun XL, Zhao JH, Murray RM, Collier DA, Li T (2008).  Correlation and familial aggregation of dimensions of psychosis in affected sibling pairs from China.  Br J Psychiatry 193: 305-310.  (Oct 2008)

  29. Zhou KX, Asherson P, Sham PC, Franke B, Anney RJL, Buitelaar J, Ebstein R, et al. (2008). Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings.  Biological Psychiatry 64: 571-576.  (Oct 2008)

  30. Hur Y-M, Kaprio J, Iacano WG, Boomsma DI, McGue M, Silventoinen K, Martin NG, Luciano M, Visscher PM, Rose RJ, He M, Ando J, Ooki S, Nonaka K, Lin CCH, Lajunen HR, Cornes BK, Bartels M, van Beijsterveldt CE, Cherny SS, Mitchell K (2008).  Genetic influences on the difference in variability of height, weight, and body mass index between Caucasian and East Asian adolescent twins.  Intl J Obesity 32: 1455-1467.  (Oct 2008)

  31. Cherny SS (2008).  Variance components and related methods for mapping quantitative trait loci.  Sociological Methods & Research 37: 227-250.  (Nov 2008)

  32. Wang Y, Leung FCC (2008).  GC content increased at CpG flanking positions of fish genes compared with sea squirt orthologs as a mechanism for reducing impact of DNA methylation.  PLoS ONE 3: e3612.  (Nov 2008)

  33. Wang Y, Leung FCC (2008).  Comparative genomic study reveals a transition from TA rich-ness in invertebrates to GC richness in vertebrates at CpG flanking sites: An indication for context-dependent mutagenicity of methylated CpG sites.  Geno Prot Bioinfo 6: 144-154.  (Nov 2008)

  34. Cheung CL, Sham PC, Chan V, Paterson AD, Luk KD, Kung AWC (2008).  Identification of LTBP2 on Chromosome 14q as a Novel Candidate Gene for Bone Mineral Density Variation and Fracture Risk Association.  J Clin Endocrinol Metabol 93: 4448-4455.  (Nov 2008)

  35. Chen W, Zhou KX, Sham PC, Franke B, Kuntsi J, Campbell D, Fleischman K, et al (2008).  DSM-IV Combined type ADHD shows familial association with sibling trait scores: a sampling strategy for QTL linkage.  Am J Med Genet Part B Neuropsychiatr Genet 147B: 1450-1460.  (Dec 2008)

  36. Yang WL, Wang ZY, Wang LS, Sham PC, Huang P, Lau YL (2008).  Predicting the number and sizes of IBD regions among family members and evaluating the family size requirement for linkage studies.  Eur J Hum Genet 16: 1535-1543.  (Dec 2008)

  37. Pittman AM, Webb E, Carvajal-Carmona L, Howarth K, Di Bernardo MC, Broderick P, Spain S, et al (2008).  Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer.  Hum Mol Genet 17: 3720-3727.  (Dec 2008)

  38. Yeung JMY, Sham PC, Chan ASW, Cherny SS (2008).  OpenADAM: an open source genome-wide association data management system for Affymetrix SNP arrays.  BMC Genomics 9: 636-639.  (Dec 2008)

  39. Zhang FQ, Xu Y, Liu P, Fan H, Huang XZ, Sun GX, Song YQ, Sham PC (2008).  Association analyses of the interaction between the ADSS and ATM genes with schizophrenia in a Chinese population.  BMC Medical Genomics 9: 119-126.  (Dec 2008)

* Co-first author
** Print date is denoted in brackets


  1. The International HapMap Consortium (2007).  A second generation human haplotype map of over 3.1 million SNPs.  Nature 449: 851-861.

  2. Kong EK, Chong WP, Wong WH, Lau CS, Chan TM, Ng PK, Song Y-Q, Mak W, Lau YL (2007).  p21 gene polymorphisms in systemic lupus erythematosus.  Rheumatology 46: 220-226.

  3. Andresen JM, Gayan J, Cherny SS, Brocklebank D, Alkorta-Aranburu G, Addis EA, The US-Venezula collaborative research group, Cardon LR, Housman DE, Wexler NS (2007).  Replication of twelve association studies for Huntington’s disease residual age of onset in large Venezuelan kindreds.   J Med Genetics 44: 44-50.

  4. Andresen JM, Gayan J, Diousse L, Roberts S, Brocklebank D, Cherny SS, The US-Venezula collaborative research group, The HD MAPS Collaborative Research Group, Cardon LR, Gusella JF, MacDonald ME, Myers RH, Houseman DE, Wexler NS (2007).  The relationship between CAG repeat length and age of onset differs for Huntington’s Disease patients with juvenile onset or adult onset.  Ann Hum Genet 71: 295-301.

  5. Goode EL, Cherny SS, Christian JC, Jarvik GO, de Andrade M (2007).  Heritability of longitudinal measures of body mass index and lipid and lipoprotein levels in aging twins.  Twin Res Hum Genet 10: 703-711.

  6. Hopfer CJ, Lessem JM, Hartman CA, Stallings MC, Cherny SS, Corley RP, Hewitt JK, Krauter KS, Mikulich-Gilbertson SK, Rhee SH, Smolen A, Young SE, Crowley TJ (2007).  A genome-wide scan for loci influencing adolescent cannabis dependence symptoms: Evidence for linkage on chromosome 3 and 9.  Drug Alcohol Depend 89: 34-41.

  7. Willer CJ, Dyment DA, Cherny SS, Ramagopalan SV, Herrera BM, Morrison KME, Sadovnick AD, Risch NJ, Ebers GC (2007).  A genome-wide scan in forty large pedigrees with multiple sclerosis.  J Hum Genet 52: 955-962.

  8. Wang Y, Fong PY, Leung FCC, Mak W, Sham PC (2007).  Increased gene coverage and Alu frequency in large linkage disequilibrium blocks of the human genome.  Genetics and Molecular Research 6: 1131-1141.

  9. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MAR, Bender D, Maller J, Sklar P, de Bakker PIW, Daly MJ, Sham PC (2007).  PLINK: A tool set for whole-genome association and population-based linkage analyses.   Am J Hum Genet 81: 559-575.

  10. Vermeulen S, Den Heijer M, Sham PC, Knight J (2007).  Application of multi-locus analytical methods to identify interacting loci in case-control studies.   Ann Hum Genet 71: 689-700.

  11. Purcell S, Daly MJ, Sham PC (2007).  WHAP: haplotype-based association analysis.  Bioinformatics 23(2): 255-56.

  12. Chan KYK, Ching JCY, Xu MS, Cheung ANY, Yip SP, Yam LYC, Lai ST, Chu CM, Wong ATY, Song Y-Q, Huang FP, Liu W, Chung PH, Leung GM, Chow EYD, Chan EYT, Chan JCK, Ngan HYS, Tam P, Chan LC, Sham PC, Chan VSF, Peiris M, Lin SCL, Khoo US (2007).  Association of ICAM3 genetic variant with severe acute respiratory syndrome.  J Infect Dis 196: 271-280.

  13. Ioannidis JPA, Ng MY, Sham PC, Zintzaras E, Lewis CM, Deng HW, Econs MJ, et al (2007).  Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass.  J Bone Miner Res 22: 173-183.

  14. Sham PC, Ao SI, Kwan JSH, Kao P, Cheung F, Fong PY, Ng MK (2007).  Combining functional and linkage disequilibrium information in the selection of tag SNPs.   Bioinformatics 23: 129-131.

  15. Wang Yu, Lam SK, Xu A (2007).  Adiponectin as a negative regulator in obesity-related mammary carcinogenesis.  Cell Res 17: 280-282.

  16. Xu A, Tso AW, Cheung BM, Wang Yu, Wat NM, Fong CH, Yeung DC, Janus ED, Sham PC, Lam SK (2007).  Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study.  Circulation 115: 1537-1543.

  17. Wang Y, Fong PY, Leung FC, Mak W, Sham PC (2007).  Increased gene coverage and Alu frequency in large linkage disequilibrium blocks of the human genome.  Genet Mol Res 6: 1131-1141.

  18. Wang Yu, Lam KS, Lam JB, Lam MC, Leung PT, Zhou MY and Xu A (2007).  Overexpression of angiopoietin-like protein 4 alters mitochondria activities and modulates methionine metabolic cycle in the liver tissues of db/db diabetic mice.  Mol Endocrinol 21: 972-986.

  19. Cheng KK, Lam KS, Wang Yu, Yu H, Carling D, Wu D, Wong C, Xu A (2007).  Adiponectin-induced eNOS activation and nitric oxide production are mediated by APPL1 in endothelial cells.  Diabetes 56: 1387-1394.

  20. Wang Yu, Lam KS, Kraegen EW, Sweeney G, Zhang J, Tso AW, Chow WS, Wat NM, Xu JY, Hoo RC and Xu A (2007).  Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance and hyperglycemia in humans.  Clinical Chemistry 53: 34-41.

  21. Saunders CL, Chiodini BD, Sham PC, Lewis CM, Abkevich V, Adeyemo AA, de Andrade M, Arya R, Berenson GS, Blangero J, Boehnke M, Borecki IB, Chagnon YC, Chen W, Comuzzie AG, Deng HW, Duggirala R, Feitosa MF, Froguel P, Hanson RL, Hebebrand J, Huezo-Dias P, Kissebah AH, Li WD, Luke A, Martin LJ, Nash M, Ohman M, Palmer LJ, Peltonen L, Perola M, Price RA, Redline S, Srinivasan SR, Stern MP, Stone S, Stringham H, Turner S, Wijmenga C, Collier DA (2007).  Meta-analysis of genome-wide linkage studies in BMI and obesity.  Obesity 15(9): 2263-75.

  22. Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, Wakutani Y, Cupples LA, Cuenco KT, Green RC, Pinessi L, Rainero I, Sorbi S, Bruni A, Duara R, Friedland R, Inzelberg R, Hampe W, Bujo H, Song Y-Q, Andersen O, Graff-Radford N, Petersen R, Dickson D, Der SD, Fraser PE, Schmitt-Ulms G, Younkin S, Mayeux R, Farrer LA, St George-Hyslop P (2007).  The sortilin-related receptor SORL1 is genetically associated with Alzheimer’s Disease.  Nature Genet 39: 168-177.

  23. Yeun M-Y, Smith DK, Cha MSYn, Wong CB, Wong BCW, Cheung KMC, Cheah KSE, Sham PC, Chan D, Song Y-Q (2007).  iCartiGD: integrated cartilage gene database for genetic study of cartilage.  BMC Genetics 8: 4.

  24. Virtanen IM, Song Y-Q, Cheung KMC, Ala-Kokko L, Karppinen J, Ho DWH, Luk KDK, Yip S-P, Leong JCY, Cheah KSE, Sham PC, Chan D (2007).  Phenotypic and population differences in the association between CILP and lumbar disc disease.  J Med Genet 44: 285-288.

  25. Chu LW, Li Y, Li Z, Cheung MBY, Leung RYH, Yik P-Y, Jin D-Y, Song Y-Q (2007).  A Novel intronic polymorphism of ABCA1 gene reveals risk for sporadic Alzheimer’s disease in Chinese.  Am J Med Genet B Neuropsychiatr Genet 144B: 1007-1013.


  1. Yu CKY, Lam CNW, Springob K, Schmidt J, Chu IK, Lo C (2006).  Constitutive accumulation of cis-piceid in transgenic Arabidopsis overexpressing a sorghum stilbene synthase sene.   Plant Cell Physiol 47: 1017-1021.

  2. Xu A, Wang Yu, Xu J-Y, Stejskal D, Tam S, Zhang J, Wat NWS, Wong W-K, Lam KSL (2006).  Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome.  Clinical Chemistry 52: 405-413.

  3. Wang Yu, Lam KSL, Chan L, Chan K-W, Lam JBB, Lam MC, Hoo RCL, Mak WWN, Cooper GJS, Xu A (2006).  Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex.   J Biol Chem 281: 16391-16400.

  4. Wang Yu, Xu Ly, Lam KSL, Lu G, Cooper GJS, Xu A (2006).  Proteomic characterization of human serum proteins associated with the fat-derived hormone adiponectin.  Proteomics 6: 3862-3870.

  5. Chan TL, Yuen ST, Kong CK, Chan Y-W, Chan ASY, Ng W-F, Tsui W-Y, Lo MWS, Wing Yip Tam, Li VSW, Leung SY (2006).  Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer.  Nature Genet 38: 1178-1183.

  6. Mao X, Chu IK, Lin B (2006).  A sheath-flow nanoelectrospray interface of microchip electrophoresis MS for glycoprotein and glycopeptide analysis.  Electrophoresis 27: 5059-5067.

  7. Shih C-H, Chu IK, Yip W-K, Lo C (2006).  Differential expression of two flavonoid 3’-hydroxylase cDNAs involved in biosynthesis of anthocyanin pigments and 3-deoxyanthocyanidin phytoalexins in sorghum.  Plant Cell Physiol 47: 1412-1419.

  8. Au W-Y, Lam V, Pang A, Chan L-C, Song Y-Q, Ma ES, Kwong Y-L (2006).  Glucose 6 phosphate dehydrogenase deficiency in female octo-, nano- and centigenarians.   J Gerontol 61: 1086-1089.

  9. Fong GCY, Kwok KHH, Song Y-Q, Cheng TS, Ho PWL, Chu ACY, Kung MHW, Chan KH, Cheung RTF, Mak W, Ramsden D, Ho SL (2006).  Clinical phenotypes of a large Chinese multigenerational kindred with autosomal dominant familial ALS due to Ile149Thr SOD1 gene mutation.  Amyotroph Lateral Scles 7: 142–149.

  10. Ong KL, Wong LYF, Man YB, Leung RYH, Song Y-Q, Lam KSL, Bernard M.Y. Cheung BMY (2006).  Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance.  Peptides 27: 1659-1667.

  11. Tai AL, Mak W, Ng PK, Chua DT, Ng MY, Fu L, Chu KK, Fang Y, Song Y-Q, Chen M, Zhang M, Sham PC, Guan XY (2006).  High-throughput loss-of-heterozygosity study of chromosome 3p in lung cancer using single-nucleotide polymorphism markers.  Cancer Res 15: 4133-4138.

  12. Chan D, Song Y-Q, Sham PC, Cheung KM (2006).   Genetics of disc degeneration.   Eur Spine J 15 Suppl 3: S317-325.

  13. Cheung KMC, Chen Y, Karppinen J, Chan D, Jeffrey JTJ, Luk KDT, Ala-Kokko L, Leong JCY, Ott J, Sham P, Cheah KSE, Song Y-Q (2006)Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in Chinese.  Spine 31: 1143-1148.

  14. Li Y, Leung WC, Chen YQ, Cheung BMY, Liang RYH, Yik PY, Ng KM, Mak W, Jin DY, St George-Hyslop P, Song Y-Q (2006).   Intron 2 (T/C) CYP46 polymorphism is associated with Alzheimer's disease in Chinese.  Dement Geriatr Cogn Disord 22: 399-404.

  15. Wang Y, Leung FCC (2006).  Long inverted repeats in eukaryotic genomes: Recombinogenic motifs determine genomic plasticity.  FEBS Letters 580: 1277-1284.

  16. Wang Y, Wang ZG, Li J, Wang YJ, Leung FCC (2006).  Database for chicken full-length cDNAs.  Physiol Genomics 28: 141-145.

  17. Wang Yu, Lam JB, Lam KS, Liu J, Lam MC, Hoo RL, Wu D, Cooper GJ and Xu A (2006).  Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice.  Cancer Res 66: 11462-11470.


  1. The International HapMap Consortium (2005).  A haplotype map of the human genome.  Nature 437: 1229-1320.

  2. Chu IK, Lam CNW (2005).  Generation of peptide radical dications via low-energy collision-induced dissociation of [CUII(terpy)(M + H)]·3+.  J Am Soc Mass Spectrom 16: 1795-1804.

  3. Chu IK, Lam CNW, Siu SO (2005).   Facile generation of tripeptides radical cations in vacuo via intramolecular electron transfer in CuII tripeptide complexes containing sterically encumbered terpyridine ligands.  J Am Soc Mass Spectrom 16: 763-771.