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Technology Seminar (14 Mar 2008)

Technology Seminar

MassARRAYTM – Solutions for Genotyping, Structural Variations and Epigenomics


Dr Darryl Irwin, PhD
Senior Scientist – Applications and Technology

on Friday, 14 March 2008 at 4:00p.m.

Room L6-32, 6/F, Laboratory Block
Genome Research Centre
21 Sassoon Road, Pokfulam, Hong Kong

Mass spectrometry of DNA (and RNA) combines the sensitivity of PCR with the specificity and precision provided by a high resolution detector. Current technology includes highly automated sample processing and completely automated data interpretation. Thus, users who know nothing about the details of mass spectrometry successfully use the platform to measure genotypes, gene expression and methylation (epigenetics).
This presentation will focus on the most recent developments of the technology in the field of SNP Genotyping, Structural Variations (CNVs) and CpG methylation analysis.
Sequenom’s iPlexTMfacilitates highly multiplexed analysis of SNPs for targeted and fine mapping studies. In addition the precision of mass spectrometry provides allele frequency measurements with a standard deviation of 1-2%. Through the incorporation of a known target the absolute number of template copies in copy number variant regions.
Sequenom’s EpityperTM provides simultaneous quantitative analysis of CpG units within entire CpG islands that is both high throughput and cost effective. Utilising this technology, we describe several broad, large-scale surveys of cancer cohorts in the search for medically significant DNA methylation biomarkers and the application of these biomarkers to cancer detection, sub-typing and prognosis.

Co-organized with SEQUENOM, Inc.

For enquiries, please call 2819-9848 or write to This e-mail address is being protected from spambots. You need JavaScript enabled to view it