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Technology Seminar (21 May 2015)



Technology Seminar

Transforming Proteomics Analysis
with Orbitrap Mass Spectrometer


Dr Wei Zhang
Application Engineer

21 May 2015 (Thu)
3:00 – 4:30pm

Seminar Room 1B, G/F
The Hong Kong Jockey Club Building for Interdisciplinary Research
5 Sassoon Road, Pokfulam, Hong Kong


As the major approach for proteomics, classical mass spectrometry (MS) faces new challenges, such as throughput limitation for large-scale protein identification, complex matrix interference for quantification, and ineffective fragmentation for PTM characterization. Recent progress in Orbitrap MS technologies permits new breakthrough in proteomics. Identification of more than 4000 proteins within one hour is realized for large-scale proteomic analysis by massive parallelization. Comprehensive characterization of intact glycopeptides with peptide sequence, site localization as well as glycan structure elucidation is achieved using latest fragmentation and MSn technologies. Quantification reproducibility and accuracy is significantly improved with novel MS workflows, including synchronous precursor selection (SPS), parallel reaction monitoring (PRM), multiplexing acquisition (MSX), and various data independent acquisition (DIA) approaches. This seminar will introduce the most recent advances in proteomic analyses, and discuss the possible development these new technologies will bring to proteomics.



Co-organized with Euro Tech (Far East) Ltd. Euro Tech (Far East) Ltd Logo
Refreshment to be served
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