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Technology Seminar (4 Oct 2016)

Technology Seminar

Towards Detection of Diagnostic microRNA

Biomarkers in Biofluids and the Functional

Analysis of Long Non-coding RNA Targets



 Dr Michael Hansen

Exiqon Seniro Scientist and Technical Specialist 

  4 October 2016 (Tue)

12 noon – 1:30 pm  

Seminar Room 1B, G/F

The Hong Kong Jockey Club Building for Interdisciplinary Research 

5 Sassoon Road, Pokfulam, Hong Kong



The investigation of extracellular microRNAs, long non-coding RNAs (lncRNAs) and their potential as pathophysiological markers has greatly expanded over the last few years. The relatively high stability of microRNAs and lncRNAs in common clinical samples (FFPE blocks, plasma, serum, urine, saliva, etc.) and the feature of microRNA and lncRNA expression profiles to accurately identify distinct tissue types, both healthy and diseased, have positioned microRNAs and lncRNAs as promising new diagnostic biomarkers in cancer and other pathologies.

Exiqon has developed the highly sensitive qPCR platform involving LNA™-modified primers, which enables detection of microRNAs of an extremely low abundance. Exiqon has also developed potent antisense oligonucleotides, so-called LNA™ Gapmer, offering highly efficient inhibition of mRNA and lncRNA function. Here, we will present how microRNA mimics and inhibitor, LNA™ GapmeR were used together for in vitro and in vivo functional analysis of transcriptional regulation in human and other mammalian systems.


Michael Hansen acquired his PhD degree at the Aarhus University (Denmark), when he focused on the analysis of gene expression and virus induced gene silencing. During his eight years with Exiqon, Dr Michael Hansen has been closely involved in R&D projects working with data analysis in Exiqon qPCR and MicroArray Services. For the last four years, working in Sales & Marketing, Michael has been providing a technical support of sales as well as was and technical questions of distributors – managing seminars – spreading the words of LNA.




Refreshment to be served

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