Research Seminar (13 Dec 2012)



Research Seminar

APG: an Active Protein-Gene Network
Model to Quantify Regulatory Signals in
Complex Biological Systems


Professor Luonan Chen

Executive Director and Professor, Key Laboratory of Systems Biology
Chinese Academy of Sciences, China

13 December 2012 (Thursday)
4:00 – 5:00pm

Seminar Room 7-03, 7/F

The Hong Kong Jockey Club Building for Interdisciplinary Research

5 Sassoon Road, Pokfulam, Hong Kong


Combinatorial interactions among transcription factors (TFs) and their cofactors collectively determine gene expression in complex biological systems. In this work, we develop a novel graphical model, called Active Protein-Gene (APG) network model, to quantify regulatory signals of transcription in complex biomolecular networks through integrating both TF upstream and downstream high-throughput data. Firstly, we theoretically and computationally demonstrate the effectiveness of APG by comparing with the traditional strategy based only on TF downstream information. We then apply this model to study spontaneous type 2 diabetic Goto-Kakizaki (GK) and Wistar control rats. APG model can find hidden TFs with changed activities as well as their network structure in diabetic GK rats. Furthermore, we identify network rewiring of TFs and their regulatory targets. For the first time, we reveal significant correlation of E2F1 and BAHD1 to GCK in Wistar controls, which, however, disappears in GK rats. Finally, our biological experiments validate the theoretical results.

About the Speaker: Professor Luonan Chen



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