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Joint Research Seminar (7 Oct 2013)


Joint Research Seminar

The Theme-based Research Scheme Project on Personalized Medicine for
Cardiovascular Diseases
Genomics Strategic Research Theme
Centre for Genomic Sciences

  7 October 2013 (Mon)

Lecture Theatre 4
Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, HK

  Part 1: 4:00 – 4:45 pm  
  Title: Genetic Association Studies of Complex Human Traits  
  Speaker: Professor Gonçalo Rocha Abecasis
Felix E Moore Collegiate Professor of Biostatistics, Department of Biostatistics, School of Public Health, University of Michigan

For the past 10 years, genetic association studies have largely focused on common variants. Recent advances in genotyping and sequencing technology have allowed these studies to extend to rare variation and pose a variety of interesting challenges for study design and analysis. I will discuss efficient study designs enabled by new genotyping and sequencing technologies as well as new methods for the analysis of the resulting data. Drawing on our work on the genetics of age-related macular degeneration and blood lipid levels, a key risk factor for cardiovascular disease, I will illustrate the discoveries that these new studies are enabling.

  Part 2: 4:45 – 5:30 pm  
  Title: Finding New Lipid Genes – What is the Right Approach?  
  Speaker: Professor Cristen Willer
Assistant Professor of Internal Medicine, Human Genetics & Computational Medicine and Bioinformatics, University of Michigan

In our quest to more completely understand the genes underlying lipid levels, a major risk factor for cardiovascular disease, we have undertaken several different approaches. We will discuss the success and pros/cons of three approaches; GWAS in a few hundred thousand individuals, sequencing in a few thousand, and high-throughput genotyping of coding variants.



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