Open Research Seminar (28 Jul 2014)



Open Research Seminar

28 July 2014 (Monday)
10:00 am – 12:00 noon

Seminar Room 3, G/F
The Hong Kong Jockey Club Building for Interdisciplinary Research
5 Sassoon Road, Pokfulam, HK


RNA-seq Data Analysis


Dr Zhenyu Xuan

University of Texas

The new sequencing technology has greatly empowered the study of transcriptome with the RNA-seq approaches. However, it is still a very challenge task to understand the biological meaning from massive sequencing data, especially when reference genome or transcriptome are unknown or incomplete. In this presentation, I will review the popular computational methods for RNA-seq data analysis to identify differentially expressed genes, isoforms, and alternative splicing events. I will also introduce the single cell RNA-seq data analysis if time permits.


ChIP-seq profiling of mouse tissues reveals dynamic enhancer landscapes and their role in development, evolution, and disease


Dr Alexander Nord

Genomics Division, Lawrence Berkeley National Lab

Non-coding regulatory elements are predicted to underlie dynamic gene expression during mammalian development and to act as a substrate for evolutionary change. Despite the assumed importance of regulatory elements in development, the landscape of enhancer activity in vivo across developmental time points has been relatively uncharted. Using a time course ChIP-seq approach, we examined the changing state of a chromatin mark associated with enhancer activity, revealing complex and widespread changes in predicted enhancer activity are associated with transient developmental processes and with patterns of vertebrate evolution. These studies have enabled further examination of the in vivo activity of mammalian and their role in development, evolution, and disease in our laboratory.


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