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Joint Research Seminar (8 Apr 2015)



Joint Research Seminar

Genomics Strategic Research Theme
Centre for Genomic Sciences

A Unifying and Scalable Framework
for Large-scale Gene

Dr Christophe Dessimoz

Laboratory of Computational Evolutionary Biology and Genomics
University College London

8 April 2015 (Wed)
2:00 – 3:00pm

Seminar Room 4
Laboratory Block, Faculty of Medicine Building

21 Sassoon Road, Pokfulam, HK

The sequencing revolution is transforming biological sciences, providing us with a wealth of information and an unprecedented opportunity to better understand the molecular basis of life. Yet because dealing with multiple species can be conceptually and practically challenging, many analyses remain stuck in a "two-species at a time" paradigm or only consider single-copy genes across multiple species. To overcome this impasse, I'll introduce the concept of Hierarchical Orthologous Groups (HOGs) - nested groups of genes descending from a single ancestral gene within clades of interest. I'll present an algorithm to accurately and efficiently infer HOGs. I will show how HOGs can be used to reconstruct ancestral genomes and to propagate functional knowledge from model species to non-model species.

About the Speaker:
Christophe Dessimoz is a lecturer (assistant professor) at University College London, where he heads the Laboratory of Computational Evolutionary Biology and Genomics. Prior to his appointment at UCL in 2013, he was a SNSF advanced fellow at EMBL European Bioinformatics Institute (Cambridge UK). Earlier, he completed his PhD at ETH Zurich, Switzerland. At the interface between biology and computer science, he seeks to better understand evolutionary and functional relationships between genes, genomes, and species. More info at http://lab.dessimoz.org and on Twitter (@DessimozLab).


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