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Joint Seminar (14 Dec 2015)

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Joint Seminar

Centre for Genomic Sciences
School of Chinese Medicine

What Is Proteomics And How This
Technique Help Us To Understand
Brain Function/Disorders

Prof Li Ka Wan

Assistant Professor
Group leader of Neuroproteomics, CNCR
VU University, Netherlands


14 December 2015 (Mon)
11 am – 12 noon


Seminar Room 3, G/F
The Hong Kong Jockey Club Building for Interdisciplinary Research
5 Sassoon Road, Pokfulam, Hong Kong


 
Abstract:

In this presentation I shall briefly describe what is proteomics. I then demonstrate how proteomics analyses facilitate our understanding of (novel) mechanistic underpins of the physiological/pathological processes of brain functions. Specially, I shall discuss (1) how to construct a comprehensive synaptic protein interactomes by large scale interaction proteomics using >100 distinct antibodies, and the challenges associated with such study; (2) to examine the alteration of proteomes in human neurodegenerative patience post-mortem brains. We use Laser Capture Microdissection to collect specific brain regions down to single cells level for subsequent proteomics analysis. Proteins that show significant changes often clustered into distinct function groups, which allow us to decipher the alteration of specific physiological processes in the disease brains.

About the Speaker:

Prof Li is currently a Group leader of Neuroproteomics (2003-present), CNCR, VU University, Netherlands. He has served as an editor and review editor in several SCI journals, including Amino Acids (2008-present); Editor of Neuroproteomics (2011); Frontiers in Neurogenomics, Review Editor (2011-present); Frontiers in Synaptic Neuroscience, Review Editor (2012-present); and Biochimica et Biophysica Acta (BBA) - Guest Editor of the special issue Neuroproteomics (2015). He obtained his bachelor’s degree in Zoology from Leeds University, UK, in 1980.
In addition, he completed his MSc in Biology/Ecology (1985) and PhD in Neurobiology (1993) from VU University. He then joined VU University as an Assistant Professor. He has published 148 international papers in prestigious journals, including Science, PNAS, Nature Neurosci., Mol Psychiatry, Neuron and BRAIN etc, with 3286 citations and an H-index of 33. He served as editor of the research book Neuroproteomics (Springer Protocols Neuromethods) with 9440 times download till early this month.

 

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