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Joint Research Seminar (27 Jan 2016)



Joint Research Seminar

Genomics Strategic Research Theme
Centre for Genomic Sciences

Transcription Factor And miRNA
Regulation In Microvesicle Inducing
Normal Cell To Cancer Cell

Dr An-Yuan Guo

Huazhong University of Science and Technology

27 January 2016 (Wed)
10:00 am – 11:30 am

Seminar Room 1B, G/F
The Hong Kong Jockey Club Building for Interdisciplinary Research

5 Sassoon Road, Pokfulam, Hong Kong


Transcription factor (TF) and miRNA are both key regulators of gene expression. What kinds of co-regulatory modules they will form and what is the function of those modules? Here, I will talk about the transcription factor and miRNA co-regulatory modules. Previous study reported the k562 microvesicles can induce normal hematopoietic transplants (mononuclear cells) to leukemia-like cells. Then we introduced NGS sequencing and analyzed the TF and miRNA co-regulation in this cell transformation. We identified the regulator networks for key pathways and validated some key molecules in the transformation. I will also introduce some bioinformatics databases we constructed for TF and miRNA.

About the Speaker:

Dr An-Yuan Guo is a professor of Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China. He received his BS from Nankai University in China and his PhD in bioinformatics in 2007 from Peking University in China. He did postdoctoral research in bioinformatics study in complex diseases at Virginia Commonwealth University and Vanderbilt University. He joined Huazhong University of Science and Technology in 2009 as a professor. He is an expert in bioinformatics database and developed a serial of databases including transcription factor (TF) databases (DATF, PlantTFDB, AnimalTFDB, miRNASNP and lncRNASNP) and disease gene databases (ERGR and CADgene). His research focuses on bioinformatics study in complex disease and next generation sequencing data analysis. He developed approaches to study the microRNA and TF co-regulatory network analysis in complex diseases and identified some key regulators. He has published more than 40 papers in molecular psychiatry, nucleic acids research, briefings in bioinformatics, bioinformatics, human mutation, scientific reports and BMC systems biology etc.



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