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Joint Research Seminar (27 Jan 2016)



Joint Research Seminar

Genomics Strategic Research Theme
Centre for Genomic Sciences

Identifying Regulatory Logics and Kinetic
Parameters Which Determines the
Dynamic Profile of Gene Expression

Dr Zhu Hailong

Assistant Professor
School of Chinese Medicine in Hong Kong Baptist University

27 January 2016 (Wed)
11:30 am – 12:30 pm

Seminar Room 1B, G/F
The Hong Kong Jockey Club Building for Interdisciplinary Research

5 Sassoon Road, Pokfulam, Hong Kong


Modeling of transcriptional regulatory networks (TRNs) has been increasingly used to dissect the nature of gene regulation. In this study, we introduced an integrative method, LogicTRN, to modeling quantitative regulatory functions using time series gene expression data and transcription factors (TFs)-DNA binding signal. The model was constructed based on regulatory logics and transcriptional kinetics that can lead to determine the underlying TF regulatory logics and the TRNs. We evaluated LogicTRN using simulation and application studies, and the results not only show consistence with existing knowledge, but also demonstrate its ability to accurately reconstruct TRNs, and to describe dynamic transcriptional profiles.

About the Speaker:

Dr Zhu Hailong is an Assistant Professor in School of Chinese Medicine in Hong Kong Baptist University. He obtained his PhD in Xi’an Jiaotong University. After graduated, he worked as Research Engineer in GE Global Research, and then as a Principal Investigator in The Hong Kong Polytechnic University. He joined the Department of Computer Science of Hong Kong Baptist University as a Research Assistant Professor in 2010. Dr Zhu was appointed as an Assistant Professor in School of Chinese Medicine in 2015. His current research interests include Bioinformatics, computational biology, systems biology, big data analytics and computer aided drug discovery.



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