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Joint Research Seminar (8 Apr 2016)



Joint Research Seminar

Centre for Genomic Sciences
Strategic Research Theme of Genomics
State Key Laboratory of Brain and Cognitive Sciences

Polygenic Risk Scores: Hype or Hope?

Dr Paul O’Reilly
Senior Lecturer in Statistical Genetics
King’s College London

8 April 2016 (Fri)
2 – 3 pm

Seminar Room 4, Room 4-02, 4/F
The Hong Kong Jockey Club Building for Interdisciplinary Research

5 Sassoon Road, Pokfulam, Hong Kong


Over the last year there has been a surge of interest in Polygenic Risk Scores (PRS), fuelled by the recent public release of large-scale GWAS data. But will this just be a passing fad or are PRS here to stay? Here I make the case that PRS will be a pivotal approach in genetics for years to come and that all research into complex phenotypes should account for and exploit their polygenicity. This requires a different way of thinking about applications of genetics in medical research. In this talk I will give an overview of the PRS method, introduce our PRSice polygenic software and illustrate some recent results from its application. I will also describe novel polygenic approaches to several areas in Genetic Epidemiology: gene*env and gene*gene interaction studies, pathway analyses, prediction of treatment response and the identification of natural selection in the human genome.

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